His laboratory collaborates with each member of this group in several ongoing projects, and they contribute to the generation of preliminary data. In addition, he has assembled a team of collaborators, such as the CCIL’s Erik Nelson (murine model of breast cancer) and Wawrzyniec Dobrucki (whole animal imaging) to support his research. Kannanganattu has extensive research experience in the field of lncRNAs, alternative splicing, and gene regulation in cancer cells. They have obtained crucial preliminary data showing that MALAT1 co-localizes with SR family of oncogenic splicing factors (SRSFs) in nuclear speckles (Tripathi et al., 2010), influences the speckle localization and splicing activity of SRSFs (Tripathi et al., 2010 2013), and regulates hypoxia-responsive AS of a large number SRSF target genes, controlling angiogenesis and metastasis in BC cells. His lab was the first to demonstrate the involvement of MALAT1 in AS (alternative splicing) of pre-mRNAs. The current application builds logically on his prior work, describing the role of lncRNAs in gene regulation, and their involvement in cancer. His lab is working to determine the molecular mechanism by which the oncogenic lncRNA, MALAT1 controls alternative splicing (AS) of pre-mRNA and utilizing hypoxia response in breast cancer cells as an experimental model system. The Cancer Center at Illinois Graduate Cancer Scholarship Program (GCSP) provides graduate students in CCIL member labs with experience preparing research proposals for supporting high-quality collaborative research conducted by those students.Prasanth Kannanganattu’s laboratory has significantly contributed to the understanding of lncRNA’s role in gene expression.
The scholarship funds will support projects starting in Fall 2021 through Spring 2022.
The other honorees of the Graduate Cancer Scholarship include Sarah Gardner (biochemistry), Yoon Jeong (bioengineering), and You Jin Song (cellular and developmental biology). He had also recently won a Beckman Institute Graduate Fellowship for his work to develop a new tool to study biological processes in space and time, in both their physical and chemical components. He will be working with his advisor, MechSE Professor Taher Saif Rohit Bhargava, CCIL Director and professor of bioengineering and Kannanganattu Prasanth, professor of cell and developmental biology.Įmon will continue his studies in tumor stiffness and whether stimulation encourages growth production of cancer cells. “Not only do CCIL scholarships accelerate cancer discoveries at Illinois, but they provide students with real-world laboratory experience on exceptional, interdisciplinary teams.”įor Emon, a PhD candidate in theoretical and applied mechanics, the CCIL scholarship will fund a project to study the simultaneous biophysical and biochemical cellular interactions in 3D cancer models. “A core mission of the Cancer Center at Illinois is to mobilize and inspire students across campus to pursue careers in cancer research,” Rex Gaskins, CCIL’s Associate Director for Education, said. MechSE graduate student Bashar Emon was one of four Illinois students who recently received a Cancer Center at Illinois (CCIL) Graduate Cancer Scholarship to pursue cancer research projects under the mentorship of CCIL scientists.
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